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AccuPower® BCR-ABL Quantitative RT-PCR Kit

In vitro diagnostic kit for the quantification of BCR-ABL mutation in human samples

Overview
Technical/Specs
Ordering Information

Philadelphia chromosome or Philadelphia translocation is a specific chromosomal abnormality that is associated with chronic myelogenous leukemia (CML). It is the result of a reciprocal translocation between chromosome 9 (region q34: ABL) and 22 (region q11: BCR). ABL gene expresses a membrane-associated protein, a tyrosine kinase, the BCR-ABL transcript is also translated into a tyrosine kinase, adding a phosphate group to tyrosine. In turn, BCR-ABL activates a number of cell cycle-controlling proteins and enzymes, speeding up cell division. Moreover, it inhibits DNA repair, causing genomic instability and potentially causing the feared blast crisis in CML.


Intended Use

The AccuPower® BCR-ABL Quantitative RT-PCR Kit is an in vitro diagnostic kit designed for the quantification of BCR-ABL (M-bcr) mutation in human samples such as whole blood and bone marrow through real-time PCR using Exicycler™ 96.

Features and Benefits

 Signature Convenience: One-step RT-PCR premix type.
All components for the assay are contained within a tube. Just add sample!
 Enhanced Sensitivity &
   Specificity:
Bioneer’s proprietary Dual HotStart technology accomplishes high sensitivity and specificity.
 Remarkable Stability: Vacuum-dried premix allows stable and reproducible results.
 High Quality: All diagnostic kits manufactured by Bioneer are under strict quality control guidelines.