AccuPower® BCR-ABL Quantitative RT-PCR Kit
Philadelphia chromosome or Philadelphia translocation is a specific chromosomal abnormality that is associated with chronic myelogenous leukemia (CML).
It is the result of a reciprocal translocation between chromosome 9 (region q34: ABL) and 22 (region q11: BCR). ABL gene expresses a membrane-associated protein,
a tyrosine kinase, the BCR-ABL transcript is also translated into a tyrosine kinase, adding a phosphate group to tyrosine. In turn, BCR-ABL activates a number
of cell cycle-controlling proteins and enzymes, speeding up cell division. Moreover, it inhibits DNA repair, causing genomic instability and potentially causing the feared blast crisis in CML.
The AccuPower® BCR-ABL Quantitative RT-PCR Kit is an in vitro diagnostic kit designed for the quantification of BCR-ABL (M-bcr) mutation in human samples such as
whole blood and bone marrow through real-time PCR using Exicycler™ 96.